COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

In higher eukaryotic cells, the p53 protein is degraded by the ubiquitin–26S proteasome system mediated by Mdm2 or the human papilloma virus E6 protein. Here we show that COP9 signalosome (CSN)-specific phosphorylation targets human p53 to ubiquitin–26S proteasome-dependent degradation. As visualize...

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Huvudupphovsmän: Bech-Otschir, Dawadschargal, Kraft, Regine, Huang, Xiaohua, Henklein, Peter, Kapelari, Barbara, Pollmann, Christian, Dubiel, Wolfgang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2001
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC145508/
https://ncbi.nlm.nih.gov/pubmed/11285227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.7.1630
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