Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding

DRP-1 is a pro-apoptotic Ca(2+)/calmodulin (CaM)-regulated serine/threonine kinase, recently isolated as a novel member of the DAP-kinase family of proteins. It contains a short extra-catalytic tail required for homodimerization. Here we identify a novel regulatory mechanism that controls its pro-ap...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Shani, Gidi, Henis-Korenblit, Sivan, Jona, Ghil, Gileadi, Opher, Eisenstein, Miriam, Ziv, Tamar, Admon, Arie, Kimchi, Adi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11230133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.5.1099
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