Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding

DRP-1 is a pro-apoptotic Ca(2+)/calmodulin (CaM)-regulated serine/threonine kinase, recently isolated as a novel member of the DAP-kinase family of proteins. It contains a short extra-catalytic tail required for homodimerization. Here we identify a novel regulatory mechanism that controls its pro-ap...

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Hlavní autoři: Shani, Gidi, Henis-Korenblit, Sivan, Jona, Ghil, Gileadi, Opher, Eisenstein, Miriam, Ziv, Tamar, Admon, Arie, Kimchi, Adi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC145456/
https://ncbi.nlm.nih.gov/pubmed/11230133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.5.1099
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