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New synthetic inhibitor to the alternative complement pathway.

The inhibitory effects of 6-amidino-2-naphthyl 4-guanidinobenzoate (FUT-175) on the activities of factor B, factor D and cobra venom factor (CVF) X Bb were examined. FUT-175 bound specifically to the Bb fragment of factor B or CVF X Bb. FUT-175 was a non-competitive inhibitor of the esterolysis of L...

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Bibliografiske detaljer
Main Authors: Ikari, N, Sakai, Y, Hitomi, Y, Fujii, S
Format: Artigo
Sprog:Inglês
Udgivet: 1983
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1454324/
https://ncbi.nlm.nih.gov/pubmed/6553561
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