Activation of Reg gene, a gene for insulin-producing β-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation

The regeneration of pancreatic islet β cells is important for the prevention and cure of diabetes mellitus. We have demonstrated that the administration of poly(ADP-ribose) synthetase/polymerase (PARP) inhibitors such as nicotinamide to 90% depancreatized rats induces islet regeneration. From the re...

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Bibliographic Details
Main Authors: Akiyama, Takako, Takasawa, Shin, Nata, Koji, Kobayashi, Seiichi, Abe, Michiaki, Shervani, Nausheen J., Ikeda, Takayuki, Nakagawa, Kei, Unno, Michiaki, Matsuno, Seiki, Okamoto, Hiroshi
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC14542/
https://ncbi.nlm.nih.gov/pubmed/11134536
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