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Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis
We have studied the ubiquitination and degradation patterns of the human securin/PTTG protein. We show that, in contrast to budding yeast pds1, securin degradation is catalyzed by both fzy (fizzy/cdc20) and fzr (fizzy-related/cdh1/hct1). Both fzy and fzr also induce the APC/C to ubiquitinate securin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2001
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145417/ https://ncbi.nlm.nih.gov/pubmed/11179223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.4.792 |
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