Enhanced Expression of S-Adenosylmethionine Synthetase Causes Overproduction of Actinorhodin in Streptomyces coelicolor A3(2)

We found that a 46-kDa protein is highly expressed in an actinorhodin-overproducing Streptomyces coelicolor A3(2) mutant (KO-179), which exhibited a low-level resistance to streptomycin. The protein was identified as S-adenosylmethionine (SAM) synthetase, which is a product of the metK gene. Enzyme...

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Bibliografiska uppgifter
Huvudupphovsmän: Okamoto, Susumu, Lezhava, Alexander, Hosaka, Takeshi, Okamoto-Hosoya, Yoshiko, Ochi, Kozo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC145329/
https://ncbi.nlm.nih.gov/pubmed/12511507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.2.601-609.2003
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