Enhanced Expression of S-Adenosylmethionine Synthetase Causes Overproduction of Actinorhodin in Streptomyces coelicolor A3(2)

We found that a 46-kDa protein is highly expressed in an actinorhodin-overproducing Streptomyces coelicolor A3(2) mutant (KO-179), which exhibited a low-level resistance to streptomycin. The protein was identified as S-adenosylmethionine (SAM) synthetase, which is a product of the metK gene. Enzyme...

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Bibliografische Detailangaben

Veröffentlicht in:	J Bacteriol
Hauptverfasser:	Okamoto, Susumu, Lezhava, Alexander, Hosaka, Takeshi, Okamoto-Hosoya, Yoshiko, Ochi, Kozo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Gene Regulation
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145329/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12511507/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.185.2.601-609.2003
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