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Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
Lectin pathway activation of C3 is known to involve target recognition by mannan-binding lectin (MBL) or ficolins and generation of classical pathway C3 convertase via cleavage of C4 and C2 by MBL-associated serine protease 2 (MASP-2). We investigated C3 activation in C2-deficient human sera and in...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1451204/ https://ncbi.nlm.nih.gov/pubmed/16670774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25982 |
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