Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2

Lectin pathway activation of C3 is known to involve target recognition by mannan-binding lectin (MBL) or ficolins and generation of classical pathway C3 convertase via cleavage of C4 and C2 by MBL-associated serine protease 2 (MASP-2). We investigated C3 activation in C2-deficient human sera and in...

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Main Authors: Selander, Barbro, Mårtensson, Ulla, Weintraub, Andrej, Holmström, Eva, Matsushita, Misao, Thiel, Steffen, Jensenius, Jens C., Truedsson, Lennart, Sjöholm, Anders G.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2006
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1451204/
https://ncbi.nlm.nih.gov/pubmed/16670774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25982
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