Airway smooth muscle prostaglandin-EP1 receptors directly modulate β2–adrenergic receptors within a unique heterodimeric complex

Multiple and paradoxical effects of airway smooth muscle (ASM) 7-transmembrane–spanning receptors activated during asthma, or by treatment with bronchodilators such as β(2)–adrenergic receptor (β(2)AR) agonists, indicate extensive receptor crosstalk. We examined the signaling of the prostanoid-EP(1)...

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Détails bibliographiques
Auteurs principaux: McGraw, Dennis W., Mihlbachler, Kathryn A., Schwarb, Mary Rose, Rahman, Fahema F., Small, Kersten M., Almoosa, Khalid F., Liggett, Stephen B.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2006
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1451203/
https://ncbi.nlm.nih.gov/pubmed/16670773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25840
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