Antithetic regulation by β-adrenergic receptors of G(q) receptor signaling via phospholipase C underlies the airway β-agonist paradox

β-adrenergic receptors (βARs) relax airway smooth muscle and bronchodilate, but chronic β-agonist treatment in asthma causes increased sensitivity to airway constriction (hyperreactivity) and is associated with exacerbations. This paradox was explored using mice with ablated βAR genes (βAR(–/–)) and...

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Bibliographic Details
Main Authors: McGraw, Dennis W., Almoosa, Khalid F., Paul, Richard J., Kobilka, Brian K., Liggett, Stephen B.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC171392/
https://ncbi.nlm.nih.gov/pubmed/12925702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318193
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