Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

BACKGROUND: In human breast cancers, amplification of chromosome 11q13 correlates with lymph node metastasis and increased mortality. To date, two genes located within this amplicon, CCND1 and EMS1, were considered to act as oncogenes, because overexpression of both proteins, respectively cyclin D1...

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Detalhes bibliográficos
Main Authors: van Rossum, Agnes GSH, van Bragt, Maaike PA, Schuuring-Scholtes, Ellen, van der Ploeg, Jan CM, van Krieken, Johan HJM, Kluin, Philip M, Schuuring, Ed
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450299/
https://ncbi.nlm.nih.gov/pubmed/16536875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-58
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