Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

BACKGROUND: In human breast cancers, amplification of chromosome 11q13 correlates with lymph node metastasis and increased mortality. To date, two genes located within this amplicon, CCND1 and EMS1, were considered to act as oncogenes, because overexpression of both proteins, respectively cyclin D1...

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Библиографические подробности
Главные авторы: van Rossum, Agnes GSH, van Bragt, Maaike PA, Schuuring-Scholtes, Ellen, van der Ploeg, Jan CM, van Krieken, Johan HJM, Kluin, Philip M, Schuuring, Ed
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2006
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450299/
https://ncbi.nlm.nih.gov/pubmed/16536875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-58
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