Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts

Mature bone-resorbing osteoclasts (OCs) mediate excessive bone loss seen in several bone disorders, including osteoporosis. Here, we showed that reveromycin A (RM-A), a small natural product with three carboxylic groups in its structure, induced apoptosis specifically in OCs, but not in OC progenito...

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Detalhes bibliográficos
Main Authors: Woo, Je-Tae, Kawatani, Makoto, Kato, Masanori, Shinki, Toshimasa, Yonezawa, Takayuki, Kanoh, Naoki, Nakagawa, Hiroshi, Takami, Masamichi, Lee, Kun Hyung, Stern, Paula H., Nagai, Kazuo, Osada, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450238/
https://ncbi.nlm.nih.gov/pubmed/16537392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505663103
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