Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein

The Ras → Raf → MEK1/2 → extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway couples mitogenic signals to cell proliferation. B-Raf and Raf-1 function within an oligomer wherein they are regulated in part by mutual transactivation. The MAPK kinase kinase (MAP3...

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Bibliographic Details
Main Authors: Chadee, Deborah N., Xu, Dazhong, Hung, Gene, Andalibi, Ali, Lim, David J., Luo, Zhijun, Gutmann, David H., Kyriakis, John M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450194/
https://ncbi.nlm.nih.gov/pubmed/16537381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510651103
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