Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population

Inherited mutations in BRCA1 and BRCA2 lead to significantly increased risks of breast and ovarian cancer. We used epidemiologic methods to evaluate the relative risks of breast cancer vs. ovarian cancer among women of Ashkenazi Jewish ancestry with inherited mutations in BRCA1 or BRCA2. The cancer...

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Hlavní autoři: Simchoni, Sharon, Friedman, Eitan, Kaufman, Bella, Gershoni-Baruch, Ruth, Orr-Urtreger, Avi, Kedar-Barnes, Inbal, Shiri-Sverdlov, Ronit, Dagan, Efrat, Tsabari, Sigal, Shohat, Mordechai, Catane, Raphael, King, Mary-Claire, Lahad, Amnon, Levy-Lahad, Ephrat
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450152/
https://ncbi.nlm.nih.gov/pubmed/16537453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511301103
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