Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene

Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for cell survival. To uncover such liabilities in Rb m...

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Detalles Bibliográficos
Autores principales: Edgar, Kyle A., Belvin, Marcia, Parks, Annette L., Whittaker, Kellie, Mahoney, Matt B., Nicoll, Monique, Park, Christopher C., Winter, Christopher G., Chen, Feng, Lickteig, Kim, Ahmad, Ferhad, Esengil, Hanife, Lorenzi, Matthew V., Norton, Amanda, Rupnow, Brent A., Shayesteh, Laleh, Tabios, Mariano, Young, Lynn M., Carroll, Pamela M., Kopczynski, Casey, Plowman, Gregory D., Friedman, Lori S., Francis-Lang, Helen L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Genetics Society of America 2005
Materias:
Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449713/
https://ncbi.nlm.nih.gov/pubmed/15744054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.036343
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