Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene

Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for cell survival. To uncover such liabilities in Rb m...

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Detalhes bibliográficos
Main Authors: Edgar, Kyle A., Belvin, Marcia, Parks, Annette L., Whittaker, Kellie, Mahoney, Matt B., Nicoll, Monique, Park, Christopher C., Winter, Christopher G., Chen, Feng, Lickteig, Kim, Ahmad, Ferhad, Esengil, Hanife, Lorenzi, Matthew V., Norton, Amanda, Rupnow, Brent A., Shayesteh, Laleh, Tabios, Mariano, Young, Lynn M., Carroll, Pamela M., Kopczynski, Casey, Plowman, Gregory D., Friedman, Lori S., Francis-Lang, Helen L.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2005
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449713/
https://ncbi.nlm.nih.gov/pubmed/15744054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.036343
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