Design of natural killer T cell activators: Structure and function of a microbial glycosphingolipid bound to mouse CD1d

Natural killer T (NKT) cells provide an innate-type immune response upon T cell receptor interaction with CD1d-presented antigens. We demonstrate through equilibrium tetramer binding and antigen presentation assays with Vα14i-positive NKT cell hybridomas that the Sphingomonas glycolipid α-galacturon...

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Bibliographic Details
Main Authors: Wu, Douglass, Zajonc, Dirk M., Fujio, Masakazu, Sullivan, Barbara A., Kinjo, Yuki, Kronenberg, Mitchell, Wilson, Ian A., Wong, Chi-Huey
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449630/
https://ncbi.nlm.nih.gov/pubmed/16537470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600285103
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