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Combining Data From Multiple Inbred Line Crosses Improves the Power and Resolution of Quantitative Trait Loci Mapping

Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); however, the resolution of QTL locations, typically ∼20 cM, means that hundreds of genes are implicated as potential can...

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Detalhes bibliográficos
Main Authors: Li, Renhua, Lyons, Malcolm A., Wittenburg, Henning, Paigen, Beverly, Churchill, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449540/
https://ncbi.nlm.nih.gov/pubmed/15654110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.033993
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