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Combining Data From Multiple Inbred Line Crosses Improves the Power and Resolution of Quantitative Trait Loci Mapping

Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); however, the resolution of QTL locations, typically ∼20 cM, means that hundreds of genes are implicated as potential can...

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Autors principals: Li, Renhua, Lyons, Malcolm A., Wittenburg, Henning, Paigen, Beverly, Churchill, Gary A.
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449540/
https://ncbi.nlm.nih.gov/pubmed/15654110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.033993
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