The Targeting of Phosphoinositide-3 Kinase Attenuates Pulmonary Metastatic Tumor Growth Following Laparotomy

OBJECTIVE: We aimed to characterize a potential role for phosphatidylinositol 3-kinase (PI3k) in leading to accelerated postoperative metastatic tumor growth. BACKGROUND: PI3k enhances tumor cell survival in part by phosphorylating Akt and reducing apoptosis. Postoperatively, apoptosis is reduced wi...

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Detalhes bibliográficos
Main Authors: Coffey, J Calvin, Wang, Jiang H., Bouchier-Hayes, David, Cotter, Tom G., Redmond, H Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1448916/
https://ncbi.nlm.nih.gov/pubmed/16432359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.sla.0000197712.71055.12
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