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Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

The Hippo signaling pathway inhibits cell growth and regulates organ size through a kinase cascade that leads to the phosphorylation and nuclear exclusion of the growth-promoting transcriptional coactivator Yes-associated protein (YAP)/Yorkie. It mediates contact inhibition of cell growth downstream...

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Detalhes bibliográficos
Main Authors: Fan, Run, Kim, Nam-Gyun, Gumbiner, Barry M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574943/
https://ncbi.nlm.nih.gov/pubmed/23359693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216462110
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