Protein Kinase C δ Activates Topoisomerase IIα To Induce Apoptotic Cell Death in Response to DNA Damage

DNA topoisomerase II is an essential nuclear enzyme that modulates DNA processes by altering the topological state of double-stranded DNA. This enzyme is required for chromosome condensation and segregation; however, the regulatory mechanism of its activation is largely unknown. Here we demonstrate...

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Bibliographic Details
Main Authors: Yoshida, Kiyotsugu, Yamaguchi, Tomoko, Shinagawa, Hirokuni, Taira, Naoe, Nakayama, Keiichi I., Miki, Yoshio
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1447416/
https://ncbi.nlm.nih.gov/pubmed/16611985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3414-3431.2006
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