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Transcription of a Donor Enhances Its Use during Double-Strand Break-Induced Gene Conversion in Human Cells

Homologous recombination (HR) mediates accurate repair of double-strand breaks (DSBs) but carries the risk of large-scale genetic change, including loss of heterozygosity, deletions, inversions, and translocations. Nearly one-third of the human genome consists of repetitive sequences, and DSB repair...

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Detalles Bibliográficos
Main Authors: Schildkraut, Ezra, Miller, Cheryl A., Nickoloff, Jac A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446947/
https://ncbi.nlm.nih.gov/pubmed/16581784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.3098-3105.2006
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