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Transcription of a Donor Enhances Its Use during Double-Strand Break-Induced Gene Conversion in Human Cells
Homologous recombination (HR) mediates accurate repair of double-strand breaks (DSBs) but carries the risk of large-scale genetic change, including loss of heterozygosity, deletions, inversions, and translocations. Nearly one-third of the human genome consists of repetitive sequences, and DSB repair...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
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American Society for Microbiology
2006
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Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1446947/ https://ncbi.nlm.nih.gov/pubmed/16581784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.3098-3105.2006 |
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