Dominant negative retinoic acid receptor initiates tumor formation in mice

BACKGROUND: Retinoic acid suppresses cell growth and promotes cell differentiation, and pharmacological retinoic acid receptor (RAR) activation is anti-tumorigenic. This begs the question of whether chronic physiological RAR activation by endogenous retinoids is likewise anti-tumorigenic. RESULTS: T...

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Main Authors: Kupumbati, Tara S, Cattoretti, Giorgio, Marzan, Christine, Farias, Eduardo F, Taneja, Reshma, Mira-y-Lopez, Rafael
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2006
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1444935/
https://ncbi.nlm.nih.gov/pubmed/16563162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-12
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