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Assembly of AUF1 with eIF4G–poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay
An AU-rich element (ARE) located in the 3′-untranslated region of many short-lived mRNAs functions as an instability determinant for these transcripts. AUF1/hnRNP D, an ARE-binding protein family consisting of four isoforms, promotes rapid decay of ARE-mRNAs. The mechanism by which AUF1 promotes rap...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440908/ https://ncbi.nlm.nih.gov/pubmed/16556936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2308106 |
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