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Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome
Factor H (FH) is the key regulator of the alternative pathway of complement. The carboxyl-terminal domains 19–20 of FH interact with the major opsonin C3b, glycosaminoglycans, and endothelial cells. Mutations within this area are associated with atypical haemolytic uremic syndrome (aHUS), a disease...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440827/ https://ncbi.nlm.nih.gov/pubmed/16601698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601052 |
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