Functional Central Polypurine Tract Provides Downstream Protection of the Human Immunodeficiency Virus Type 1 Genome from Editing by APOBEC3G and APOBEC3B

Lentiviruses utilize two polypurine tracts for initiation of plus-strand viral DNA synthesis. We have examined to what extent human immunodeficiency virus type 1 plus-strand initiation at the central polypurine tract (cPPT) could protect the viral genome from DNA editing by APOBEC3G and APOBEC3B. Th...

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Autori principali: Wurtzer, Sebastien, Goubard, Armelle, Mammano, Fabrizio, Saragosti, Sentob, Lecossier, Denise, Hance, Allan J., Clavel, François
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440420/
https://ncbi.nlm.nih.gov/pubmed/16537639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3679-3683.2006
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