Mutagenesis Analysis of the nsp4 Main Proteinase Reveals Determinants of Arterivirus Replicase Polyprotein Autoprocessing

Nonstructural protein 4 (nsp4; 204 amino acids) is the chymotrypsin-like serine main proteinase of the arterivirus Equine arteritis virus (order Nidovirales), which controls the maturation of the replicase complex. nsp4 includes a unique C-terminal domain (CTD) connected to the catalytic two-β-barre...

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Bibliographic Details
Main Authors: van Aken, Danny, Snijder, Eric J., Gorbalenya, Alexander E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440411/
https://ncbi.nlm.nih.gov/pubmed/16537610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3428-3437.2006
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