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A Simian Virus 5 (SV5) P/V Mutant Is Less Cytopathic than Wild-Type SV5 in Human Dendritic Cells and Is a More Effective Activator of Dendritic Cell Maturation and Function

Human epithelial cells infected with the parainfluenza virus simian virus 5 (SV5) show minimal activation of host cell interferon (IFN), cytokine, and cell death pathways. In contrast, a recombinant SV5 P/V gene mutant (rSV5-P/V-CPI(−)) overexpresses viral gene products and is a potent inducer of IF...

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Detalhes bibliográficos
Main Authors: Arimilli, Subhashini, Alexander-Miller, Martha A., Parks, Griffith D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440371/
https://ncbi.nlm.nih.gov/pubmed/16537609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3416-3427.2006
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