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Kinetic analysis of sodium channel block by internal methylene blue in pronased crayfish giant axons.

The cationic dye methylene blue (MB+) blocks INa in a voltage and time-dependent manner and exhibits no frequency dependent block at 1 Hz when internally perfused in normal or pronase-treated crayfish axons. Peak INa decreases with increasing MB+ concentrations in the range 50 microM to 5 mM, but th...

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Detalhes bibliográficos
Main Authors: Starkus, J G, Heggeness, S T, Rayner, M D
Formato: Artigo
Idioma:Inglês
Publicado em: 1984
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435045/
https://ncbi.nlm.nih.gov/pubmed/6089923
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