EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts

BACKGROUND: Fourteen-membered ring macrolides have been effective in reducing chronic airway inflammation and also preventing lung injury and fibrosis in bleomycin-challenged mice via anti-inflammatory effects. EM703 is a new derivative of erythromycin (EM) without the bactericidal effects. We inves...

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Autores principales: Li, Ying Ji, Azuma, Arata, Usuki, Jiro, Abe, Shinji, Matsuda, Kuniko, Sunazuka, Toshiaki, Shimizu, Takako, Hirata, Yukiyo, Inagaki, Hirofumi, Kawada, Tomoyuki, Takahashi, Satoru, Kudoh, Shoji, Omura, Satoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1434738/
https://ncbi.nlm.nih.gov/pubmed/16438734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-7-16
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