Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

BACKGROUND: Bone marrow-derived fibrocytes reportedly play important roles in the pathogenesis of idiopathic pulmonary fibrosis. Pirfenidone is an anti-fibrotic agent; however, its effects on fibrocytes have not been investigated. The aim of this study was to investigate whether pirfenidone inhibits...

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Hauptverfasser: Inomata, Minoru, Kamio, Koichiro, Azuma, Arata, Matsuda, Kuniko, Kokuho, Nariaki, Miura, Yukiko, Hayashi, Hiroki, Nei, Takahito, Fujita, Kazue, Saito, Yoshinobu, Gemma, Akihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930125/
https://ncbi.nlm.nih.gov/pubmed/24507087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-16
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