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Predicting genes for orphan metabolic activities using phylogenetic profiles

Homology-based methods fail to assign genes to many metabolic activities present in sequenced organisms. To suggest genes for these orphan activities we developed a novel method that efficiently combines local structure of a metabolic network with phylogenetic profiles. We validated our method using...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Lifeng, Vitkup, Dennis
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1431735/
https://ncbi.nlm.nih.gov/pubmed/16507154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2006-7-2-r17
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