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Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450

Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection. We have created an artificial family comprising ˜3,000 P450 heme proteins that correctly fold and incorporate a heme...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Otey, Christopher R, Landwehr, Marco, Endelman, Jeffrey B, Hiraga, Kaori, Bloom, Jesse D, Arnold, Frances H
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1431580/
https://ncbi.nlm.nih.gov/pubmed/16594730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040112
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