Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates remain unclear. We show here that cystamine increases levels of the heat shock DnaJ-containing protein 1b (HSJ1b) that are low in HD patients....

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Detalhes bibliográficos
Main Authors: Borrell-Pagès, Maria, Canals, Josep M., Cordelières, Fabrice P., Parker, J. Alex, Pineda, José R., Grange, Ghislaine, Bryson, Elzbieta A., Guillermier, Martine, Hirsch, Etienne, Hantraye, Philippe, Cheetham, Michael E., Néri, Christian, Alberch, Jordi, Brouillet, Emmanuel, Saudou, Frédéric, Humbert, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430359/
https://ncbi.nlm.nih.gov/pubmed/16604191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27607
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