Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates remain unclear. We show here that cystamine increases levels of the heat shock DnaJ-containing protein 1b (HSJ1b) that are low in HD patients....

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Hauptverfasser: Borrell-Pagès, Maria, Canals, Josep M., Cordelières, Fabrice P., Parker, J. Alex, Pineda, José R., Grange, Ghislaine, Bryson, Elzbieta A., Guillermier, Martine, Hirsch, Etienne, Hantraye, Philippe, Cheetham, Michael E., Néri, Christian, Alberch, Jordi, Brouillet, Emmanuel, Saudou, Frédéric, Humbert, Sandrine
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430359/
https://ncbi.nlm.nih.gov/pubmed/16604191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27607
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