Phosphorylation of the Cyclin-Dependent Kinase Inhibitor p21(Cip1) on Serine 130 Is Essential for Viral Cyclin-Mediated Bypass of a p21(Cip1)-Imposed G(1) Arrest

K cyclin encoded by Kaposi's sarcoma-associated herpesvirus confers resistance to the cyclin-dependent kinase (cdk) inhibitors p16(Ink4A), p21(Cip1), and p27(Kip1) on the associated cdk6. We have previously shown that K cyclin expression enforces S-phase entry on cells overexpressing p27(Kip1)...

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Main Authors: Järviluoma, Annika, Child, Emma S., Sarek, Grzegorz, Sirimongkolkasem, Papinya, Peters, Gordon, Ojala, Päivi M., Mann, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430279/
https://ncbi.nlm.nih.gov/pubmed/16508017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2430-2440.2006
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