Alpha-Fetoprotein Controls Female Fertility and Prenatal Development of the Gonadotropin-Releasing Hormone Pathway through an Antiestrogenic Action

It has been shown previously that female mice homozygous for an alpha-fetoprotein (AFP) null allele are sterile as a result of anovulation, probably due to a defect in the hypothalamic-pituitary axis. Here we show that these female mice exhibit specific anomalies in the expression of numerous genes...

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Autors principals: De Mees, Christelle, Laes, Jean-François, Bakker, Julie, Smitz, Johan, Hennuy, Benoît, Van Vooren, Pascale, Gabant, Philippe, Szpirer, Josiane, Szpirer, Claude
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430253/
https://ncbi.nlm.nih.gov/pubmed/16479017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.5.2012-2018.2006
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