A CTCF-Dependent Silencer Located in the Differentially Methylated Area May Regulate Expression of a Housekeeping Gene Overlapping a Tissue-Specific Gene Domain

The tissue-specific chicken α-globin gene domain represents one of the paradigms, in terms of its constitutively open chromatin conformation and the location of several regulatory elements within the neighboring housekeeping gene. Here, we show that an 0.2-kb DNA fragment located ∼4 kb upstream to t...

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Autors principals: Klochkov, Denis, Rincón-Arano, Héctor, Ioudinkova, Elena S., Valadez-Graham, Viviana, Gavrilov, Alexey, Recillas-Targa, Félix, Razin, Sergey V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430243/
https://ncbi.nlm.nih.gov/pubmed/16478981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.5.1589-1597.2006
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