PlyPH, a Bacteriolytic Enzyme with a Broad pH Range of Activity and Lytic Action against Bacillus anthracis

We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel ther...

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Hlavní autoři: Yoong, Pauline, Schuch, Raymond, Nelson, Daniel, Fischetti, Vincent A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Molecular Biology of Pathogens
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1428399/
https://ncbi.nlm.nih.gov/pubmed/16547060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.188.7.2711-2714.2006
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