Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium

Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as...

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Bibliographic Details
Main Authors: Yoong, Pauline, Schuch, Raymond, Nelson, Daniel, Fischetti, Vincent A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Bacteriophages, Transposons, and Plasmids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC438584/
https://ncbi.nlm.nih.gov/pubmed/15231813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.14.4808-4812.2004
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