Involvement of the MexXY-OprM Efflux System in Emergence of Cefepime Resistance in Clinical Strains of Pseudomonas aeruginosa

Cefepime (FEP) and ceftazidime (CAZ) are potent β-lactam antibiotics with similar MICs (1 to 2 μg/ml) for wild-type strains of Pseudomonas aeruginosa. However, recent epidemiological studies have highlighted the occurrence of isolates more resistant to FEP than to CAZ (FEP(r)/CAZ(s) profile). We thu...

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Bibliographische Detailangaben
Hauptverfasser: Hocquet, Didier, Nordmann, Patrice, El Garch, Farid, Cabanne, Ludovic, Plésiat, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426951/
https://ncbi.nlm.nih.gov/pubmed/16569851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1347-1351.2006
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