IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

Neurogenin 3 (Ngn3) is key for endocrine cell specification in the embryonic pancreas and induction of a neuroendocrine cell differentiation program by misexpression in adult pancreatic duct cells. We identify the gene encoding IA1, a zinc-finger transcription factor, as a direct target of Ngn3 and...

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Hauptverfasser: Mellitzer, Georg, Bonné, Stefan, Luco, Reini F, Van De Casteele, Mark, Lenne-Samuel, Nathalie, Collombat, Patrick, Mansouri, Ahmed, Lee, Jacqueline, Lan, Michael, Pipeleers, Daniel, Nielsen, Finn C, Ferrer, Jorge, Gradwohl, Gérard, Heimberg, Harry
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1422151/
https://ncbi.nlm.nih.gov/pubmed/16511571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601011
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