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Inhibition of T-cell mediated cytotoxicity by Novobiocin suggests multiple pathways for both CD4+ and CD8+ cytotoxic T cells.

The effect of the topoisomerase II inhibitor Novobiocin on T-cell mediated cytotoxicity was tested under various assay conditions. When effector cells were class I major histocompatibility complex (MHC)-specific CD8+ cytotoxic T cells (Tc), Novobiocin caused a biphasic pattern of inhibition and the...

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Main Authors: Wood, P J, Stansfield, A G
格式: Artigo
語言:Inglês
出版: 1992
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1421699/
https://ncbi.nlm.nih.gov/pubmed/1356096
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