High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells

OBJECTIVE: To screen a library of small chemicals for compounds that activate the DPC4 signal transduction pathway in a human pancreatic cancer cell line. SUMMARY BACKGROUND DATA: Various tumor-suppressor genes are mutated in all human cancers. Specifically, DPC4 (deleted in pancreatic carcinoma, lo...

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Bibliographic Details
Main Authors: Sohn, Taylor A., Su, Gloria H., Ryu, Byungwoo, Yeo, Charles J., Kern, Scott E.
Format: Artigo
Language:Inglês
Published: 2001
Subjects:
Scientific Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1421310/
https://ncbi.nlm.nih.gov/pubmed/11323508
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