Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy

The aureolic acid antibiotic mithramycin (MTM) binds selectively to GC-rich DNA sequences and blocks preferentially binding of proteins, like Sp1 transcription factors, to GC-rich elements in gene promoters. Genetic approaches can be applied to alter the MTM biosynthetic pathway in the producing mic...

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Main Authors: Albertini, Veronica, Jain, Aklank, Vignati, Sara, Napoli, Sara, Rinaldi, Andrea, Kwee, Ivo, Nur-e-Alam, Mohammad, Bergant, Julia, Bertoni, Francesco, Carbone, Giuseppina M., Rohr, Jürgen, Catapano, Carlo V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1420802/
https://ncbi.nlm.nih.gov/pubmed/16571899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl063
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