Endoproteolytic Processing of RhoA by Rce1 Is Required for the Cleavage of RhoA by Yersinia enterocolitica Outer Protein T

The bacterial toxin Yersinia outer protein T (YopT) is a cysteine protease that cleaves Rho GTPases immediately upstream of a carboxyl-terminal isoprenylcysteine. By clipping off the lipid anchor, YopT releases Rho GTPases from membranes, resulting in rounding up of mammalian cells in culture. The p...

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Bibliographische Detailangaben
Hauptverfasser: Fueller, Florian, Bergo, Martin O., Young, Stephen G., Aktories, Klaus, Schmidt, Gudula
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418669/
https://ncbi.nlm.nih.gov/pubmed/16495543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.3.1712-1717.2006
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