Structural Analysis of the Interaction between Shiga Toxin B Subunits and Linear Polymers Bearing Clustered Globotriose Residues

We previously developed linear polymers bearing clustered trisaccharides of globotriaosylceramide (Gb3) as orally applicable Shiga toxin (Stx) neutralizers. Here, using a Gb3 polymer with a short spacer tethering the trisaccharide to the core, we found that shortening the spacer length markedly redu...

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Hlavní autoři: Watanabe, Miho, Igai, Katsura, Matsuoka, Koji, Miyagawa, Atsushi, Watanabe, Toshiyuki, Yanoshita, Ryohei, Samejima, Yuji, Terunuma, Daiyo, Natori, Yasuhiro, Nishikawa, Kiyotaka
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418665/
https://ncbi.nlm.nih.gov/pubmed/16495579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.3.1984-1988.2006
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