Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice.

We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction...

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Hauptverfasser: Mengozzi, M, Fantuzzi, G, Faggioni, R, Marchant, A, Goldman, M, Orencole, S, Clark, B D, Sironi, M, Benigni, F, Ghezzi, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414809/
https://ncbi.nlm.nih.gov/pubmed/7927490
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