Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication

We report a genome-wide analysis of single-stranded DNA formation during DNA replication in wild type and checkpoint-deficient rad53 yeast cells in the presence of hydroxyurea. In wild type cells, ssDNA first appears at a subset of replication origins and later “migrates” bi-directionally, suggestin...

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Bibliographic Details
Main Authors: Feng, Wenyi, Collingwood, David, Boeck, Max E., Fox, Lindsay A., Alvino, Gina M., Fangman, Walton L., Raghuraman, M. K., Brewer, Bonita J.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414058/
https://ncbi.nlm.nih.gov/pubmed/16429127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1358
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