Cystine/Glutamate Exchange Regulates Metabotropic Glutamate Receptor Presynaptic Inhibition of Excitatory Transmission and Vulnerability to Cocaine Seeking

Withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus accumbens by decreasing cystine/glutamate exchange (xc-). Activating xc- with N-acetylcysteine restores extracellular glutamate and prevents cocaine-induced drug seeking. It was hypothesized that the activation of...

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Detalhes bibliográficos
Main Authors: Moran, Megan M., McFarland, Krista, Melendez, Roberto I., Kalivas, Peter W., Seamans, Jeremy K.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413952/
https://ncbi.nlm.nih.gov/pubmed/16000629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1007-05.2005
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