Cystine/Glutamate Exchange Regulates Metabotropic Glutamate Receptor Presynaptic Inhibition of Excitatory Transmission and Vulnerability to Cocaine Seeking

Withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus accumbens by decreasing cystine/glutamate exchange (xc-). Activating xc- with N-acetylcysteine restores extracellular glutamate and prevents cocaine-induced drug seeking. It was hypothesized that the activation of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Moran, Megan M., McFarland, Krista, Melendez, Roberto I., Kalivas, Peter W., Seamans, Jeremy K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2005
Pynciau:
Brief Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413952/
https://ncbi.nlm.nih.gov/pubmed/16000629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1007-05.2005
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